2352 T?&gt;?C SNP had a significantly higher meat ratio ( P ? = ?0.002) and lower back-fat thickness ( P ? = ?0.004) than those of the other genotype. Moreover, although the least square means of steers with CC-CC, CT-CC, and TT-CC genotypes were significantly decreased for back-fat thickness, they were significantly increased for the meat ratio. Therefore, our results suggested that g.111 T?&gt;?C SNP and g.2352 T?&gt;?C SNP could be a causal mutation related to an adipose metabolism in Korean cattle steer.The use of specialized meat breeds in cattle breeding programs is considered very promising for improving herds' productivity. However, in animal genotype, along with genes that positively affect the productivity signs, there are genes whose mutations, known as genetic defects, negatively affect the health of animals. The aim of the study was the screening of the Russian populations of Aberdeen Angus, Hereford and Belgian Blue cattle on gene mutations associated with the genetic defects of arthrogryposis multiplex (AM), osteopetrosis (OS), developmental duplication (DD), double muscling (M1), hypotrichosis (HY) and maple syrup urine disease (MSUD) as well as the F94L polymorphism of myostatin gene (MSTN) linked with the gene responsible for less fat content in the carcass by means of DNA analysis. In the article, test systems based on the polymerase chain reaction method are presented. The analysis of the Aberdeen Angus ( n = 4480 ) population has revealed 0.19? ± ?0.09?% animal M1 carriers, 0.53? ± ?0.03?% OS carriers, 1.92? ± ?0.09?% AM carriers and 9.00? ± ?0.20?% DD carriers. The genotyping of Hereford cattle of Russian populations ( n = 525 ) has not revealed any individual carriers of MSUD or HY genetic defects. All of the Belgian Blue population ( n = 92 ) animals were heterozygous M1 carriers. The study of the F94LMSTN polymorphism has demonstrated extremely high frequencies of the desirable A allele (0.93 and 0.90) in two Aberdeen Angus populations with an average mean of 0.63? ± ?0.08, which was 32?% higher compared to the Belgian Blue population. The results suggest the high genetic potential of the Aberdeen Angus and Belgian Blue cattle, but the existence in the genotypes of the mutant alleles associated with hereditary diseases indicates the risk of uncontrolled use of these breeds.Chickens kept under free-range, backyard or semi-intensive systems in the developing countries have more diverse use and benefits to rural households. Their use varies from region to region and from community to community within a region. The study investigated growth, laying performance and survivability of six improved dual-purpose breeds in five agroecologies of Nigeria represented by the following states Kebbi (Sudan savanna/northern Guinea savanna); Kwara (northern Guinea savanna/southern Guinea savanna); Nasarawa (southern Guinea savanna/derived savanna); Imo (lowland rainforest/swamp); and Rivers (freshwater swamp/mangrove swamp). On-farm data were obtained from 2100 smallholder poultry farmers that received an average of 30 birds (mixed sexes) of any one of the following dual-purpose breeds (Fulani, FUNAAB Alpha, Kuroiler, Noiler, Sasso and Shika-Brown) randomly allocated to them. The farmers used the backyard, scavenging system of management. Body weight and mortality records for cocks were taken for 18 weeks, while body weight, mortality, egg production and egg weight data were collected for hens up to 72 weeks. Compared with the local cocks (680?g), Kuroiler (1391?g), Sasso (1398?g) and Noiler (1461?g) had over 200?% body weight at 18 weeks. Hen day egg production (HDEP) was higher in Shika-Brown (45.9?%), FUNAAB Alpha (45.8?%) and Kuroiler (45.7?%) compared with the other breeds. Fulani, FUNAAB Alpha and Shika-Brown had higher survivabilities ( p ?Fulani. The performance of the breeds was significantly ( p less then 0.05 ) influenced by the agroecologies. The cock body weights for Fulani (1121.1?g), FUNAAB Alpha (1502.4?g) and Noiler (1459.2?g) were highest in Kebbi, while for Kuroiler (1561.0?g), Sasso (1695.9?g) and Shika-Brown (1131.6?g) cock body weights were highest in Imo. Across the states, Imo had the highest HDEP (62.8?%). Overall, the lowland rainforest/ freshwater swamp agroecologies supported the highest production performance of the breeds.Finding out the genetic mechanism of growth and development traits and the development of related molecular markers can help improve the breeding of livestock. The long-chain acyl coenzyme A synthase 1 (ACSL1) gene plays a major role in lipid synthesis and fatty acid catabolism. However, there are few studies on the ACSL1 gene polymorphism of Dezhou donkeys. This study analyzed the expression level of the ACSL1 gene in different tissues of young and adult Dezhou donkeys, as well as association analysis of four gene polymorphic loci in 450 individuals. https://www.selleckchem.com/products/hmpl-504-azd6094-volitinib.html The results showed that expression levels of the ACSL1 gene are higher in heart, liver, spleen, lung, renal, gastric and muscle tissues of adult donkeys than in those of young donkeys. In the association analysis between genotype and body size traits, the wild genotype DD at the ACSL1-1 locus in female and male donkeys was greater than the mutant genotype II ( P less then 0.05 ); genotype II of ACSL1-2 was significantly higher than that of DD in withers height, body length, rump width and body weight of male donkeys ( P less then 0.05 ); and ACSL1-3 showed a tendency for the wild genotype II to be greater than the mutant genotype DD in female and male donkeys ( P less then 0.05 ). In addition, among the five haplotype combinations constructed, Hap3Hap3 (II-II-DD-DD) and Hap6Hap6 (DD-II-II-II) haplotype combinations were superior to other haplotype combinations in growth traits, which also indicated that the results of haplotype combination association analysis and genotype association analysis tended to be the same. In conclusion, the results of this study indicate that the polymorphic loci of the ACSL1 gene can be used as candidate molecular markers for the growth and development of Dezhou donkeys, and provide a theoretical reference for the breeding of Dezhou donkeys.